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Afoxin

Afoxin

 

Generic:

Clarithromycin

 

Therapeutic Class:

 

Macrolides

 
 

Composition:

 

Each Afoxin tablet contains 250
mg or 500 mg of clarithromycin.

 
 

Description:

 

Afoxin (clarithromycin) is a
semi-synthetic macrolide antibiotic.

 
 

Indications:

 

Afoxin tablets are indicated for
the treatment of mild to moderate infections caused by susceptible strains
of the designated microorganisms in the conditions as listed below:

 

Adults & Children:

  • Pharyngitis/tonsillitis 
  • Acute maxillary sinusitis 
  • Acute bacterial exacerbation of chronic bronchitis (for adults)
  • Community-Acquired Pneumonia 
  • Uncomplicated skin and skin structure infections 
  • Afoxin (clarithromycin) tablets in combination with amoxicillin and lansoprazole or  omeprazole, as triple therapy, are indicated for the treatment of patients with H.  pylori infection and duodenal ulcer disease to eradicate H. pylori (for adults).
  • Afoxin tablets in combination with omeprazole capsules or ranitidine bismuth citrate tablets are also indicated for the treatment of patients with an active duodenal ulcer associated with H. pylori infection (for adults). 
 
 

Dosage:

 

Afoxin (clarithromycin) tablets
may be given with or without food.

 

Adults & Children :

H. pylori eradication to reduce
the risk of duodenal ulcer recurrence

 

Triple
therapy: Afoxin/lansoprazole/amoxicillin

The recommended adult dose is
500 mg Afoxin, 30 mg lansoprazole, and 1 gram amoxicillin, all given twice
daily (q12h) for 10 or 14 days.

 

Triple
therapy: Afoxin/omeprazole/amoxicillin

The recommended adult dose is
500 mg Afoxin, 20 mg omeprazole, and 1 gram amoxicillin, all given twice
daily (q12h) for 10 days.

 

Dual
therapy: Afoxin/omeprazole

The recommended adult dose is
500 mg Afoxin given three times daily (q8h) and 40 mg omeprazole given once
daily (qAM) for 14 days.

 

Dual
therapy: Afoxin/ranitidine bismuth citrate

The recommended adult dose is
500 mg Afoxin given twice daily (q12h) or three times daily (q8h) and 400
mg ranitidine bismuth citrate given twice daily (q12h) for 14 days.

 

Children:

The usual recommended daily
dosage is 15 mg/kg/day divided q12h for 10 days.

PEDIATRIC
DOSAGE GUIDELINES 

Based on body weight dosing calculated on
7.5 mg/kg

Weight

Dose(q12h)

Kg

lbs

17

37

125 mg

25

55

187.5 mg

33

73

250 mg

  • For pharyngitis/tonsillitis: 250 mg (q12h) for 10 days
  • For acute maxillary sinusitis: 500 mg (q12h) for 14 days
  • For acute exacerbation of chronic bronchitis: 250 mg – 500 mg (q12h) for 7-14 days
  • For community-acquired pneumonia: 250 mg (q12h) for 7-14 days
  • For uncomplicated skin & skin structure infections: 250 mg (q12h) for 7-14 days

 

Presentations:

 
  • Afoxin 250 mg tablet is available in the pack of 10’s.
  • Afoxin 500 mg tablet is available in the pack of 10’s.