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Rubiject Injection
Iron sucrose
Therapeutic Class:
Iron preparations
Each 5 ml of Rubiject ampoule contains:
Iron sucrose equivalent to elemental iron ... 100 mg
Rubiject (iron sucrose injection) is an aqueous complex of polynuclear iron (III)-hydroxide in sucrose for intravenous use.
Rubiject is recommended in:
  • Conditions in which there is clinical requirement for rapid iron supply
  • Active inflammatory bowel disease where oral iron preparations are ineffective
  • Iron deficiency due to other reasons like final stages of pregnancy, non-responsiveness or non-compliance to oral iron therapy, malabsorption, before and after surgery etc.
Rubiject is also indicated in the treatment of iron deficiency anaemia in chronic kidney disease patients who are:
  • Non-dialysis dependent patients receiving or not receiving an erythropoietin
  • Peritoneal dialysis dependent / hemodialysis dependent patients who are receiving an erythropoietin
Rubiject injection 5-10 ml (100-200 mg iron) 1-3 times / week depending on the haemoglobin level.
Rubiject injection should be administered intravenously by slow injection or infusion.

Under study conditions, there is limited data available. If there is clinical requirement, Rubiject is recommended not to exceed 0.15 ml (3 mg iron)/kg body weight 1-3 times/week depending on the haemoglobin level also.

Recommended Adult Dosage(Chronic kidney disease patients):

Hemodialysis Dependent:
Undiluted Rubiject can be administered as 100 mg slow IV injection in 2-5 minutes or as an infusion of 100 mg, diluted in a maximum of 100 ml of 0.9% NaCl in atleast 15 minutes per consecutive hemodialysis session for a total dose of 1000 mg.

Non-Dialysis Dependent:
Rubiject is administered as a total dose of 1000 mg in 14 days as 200 mg slow IV injection undiluted in 2-5 minutes on 5 different occasions within 14 days.

Peritoneal Dialysis Dependent:
Rubiject administered as a total dose of 1000 mg in 3 divided doses, given by slow IV infusion, within 28 days: 2 infusions of 300 mg in 1 hours 14 days apart followed by one 400 mg infusion in 2 hours 14 days later. The Rubiject dose should be diluted in a maximum of 250 ml of 0.9% NaCl.
Inj 5s