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PRODUCT
Rubiject Injection
 
Generic:
Iron sucrose
 
Therapeutic Class:
Iron preparations
 
Composition:
Each 5 ml of Rubiject ampoule contains:
Iron sucrose equivalent to elemental iron ... 100 mg
 
Description:
Rubiject (iron sucrose injection) is an aqueous complex of polynuclear iron (III)-hydroxide in sucrose for intravenous use.
 
Indications:
Rubiject is recommended in:
  • Conditions in which there is clinical requirement for rapid iron supply
  • Active inflammatory bowel disease where oral iron preparations are ineffective
  • Iron deficiency due to other reasons like final stages of pregnancy, non-responsiveness or non-compliance to oral iron therapy, malabsorption, before and after surgery etc.
Rubiject is also indicated in the treatment of iron deficiency anaemia in chronic kidney disease patients who are:
  • Non-dialysis dependent patients receiving or not receiving an erythropoietin
  • Peritoneal dialysis dependent / hemodialysis dependent patients who are receiving an erythropoietin
 
Dosage:
Adults:
Rubiject injection 5-10 ml (100-200 mg iron) 1-3 times / week depending on the haemoglobin level.
Rubiject injection should be administered intravenously by slow injection or infusion.

Children:
Under study conditions, there is limited data available. If there is clinical requirement, Rubiject is recommended not to exceed 0.15 ml (3 mg iron)/kg body weight 1-3 times/week depending on the haemoglobin level also.

Recommended Adult Dosage(Chronic kidney disease patients):

Hemodialysis Dependent:
Undiluted Rubiject can be administered as 100 mg slow IV injection in 2-5 minutes or as an infusion of 100 mg, diluted in a maximum of 100 ml of 0.9% NaCl in atleast 15 minutes per consecutive hemodialysis session for a total dose of 1000 mg.

Non-Dialysis Dependent:
Rubiject is administered as a total dose of 1000 mg in 14 days as 200 mg slow IV injection undiluted in 2-5 minutes on 5 different occasions within 14 days.

Peritoneal Dialysis Dependent:
Rubiject administered as a total dose of 1000 mg in 3 divided doses, given by slow IV infusion, within 28 days: 2 infusions of 300 mg in 1 hours 14 days apart followed by one 400 mg infusion in 2 hours 14 days later. The Rubiject dose should be diluted in a maximum of 250 ml of 0.9% NaCl.
 
Presentations:
Inj 5s