Calcium dobesilate acts on the capillary walls by regulating its impaired physiological functions-increased permeability and decreased resistance. It increases erythrocyte flexibility, inhibits platelet hyperaggregation and in diabetic retinopathy, it reduces plasma and blood hyperviscosity, thus improving blood rheological properties and tissue irrigation. These effects allow to correct capillary dysfunctions either of functional origin or caused by constitutional or acquired metabolic disorders. Calcium dobesilate contributes to reduce edema.