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AG-Vono

Generic:

Vonoprazan
 

Therapeutic Class:

Proton Pump Inhibitor

 

Composition:

Each AG-Vono tablet contains 10 mg or 20 mg of Vonoprazan.
 

Description:

AG-Vono (Vonoprazan) is a first-in-class potassium-competitive acid blocker medication.

 

Indications:

AG-Vono is indicated for:

  • Treatment of gastric ulcer
  • Treatment of duodenal ulcer
  • Treatment of reflux esophagitis
  • Maintenance treatment of reflux esophagitis in patients with repeat recurrence and relapse of the condition
  • Prevention of recurrence of gastric ulcer or duodenal ulcer during NSAIDs administration
  • Adjunctive effect on eradication of Helicobacter pylori

Dosage:

Adults

Gastric ulcer
• The usual dose is AG-Vono Tab 20 mg once daily. Administration – Limited to 8 weeks.Duodenal ulcer
• The usual dose is AG-Vono Tab 20 mg once daily. Administration – Limited to 6 weeks.

Reflux esophagitis (erosive esophagitis)
• The usual dose is AG-Vono Tab 20 mg once daily. Administration – Limited to 4 – 8 weeks.

• In addition, for the maintenance of healing of reflux esophagitis in patients with repeat recurrence and relapse of the condition, a dose of AG-Vono Tab 10 mg is administered once daily; however, when the efficacy is inadequate, a dose of AG-Vono Tab 20 mg may be administered once daily. The duration of administration in the long-term efficacy clinical Study is up to 52 weeks.

Prevention of recurrence of gastric ulcer or duodenal ulcer during NSAIDs administration
• The usual dose is AG-Vono Tab 10 mg once daily.

Adjunct to Helicobacter pylori eradication
• Usually, the following 3 drugs are orally administered at the same time twice daily for 7 days: AG-Vono Tab 20 mg, 750 mg amoxicillin, and 200 mg clarithromycin. The dose of clarithromycin may be appropriately increased as required, however, the upper limit is 400 mg twice daily.

• If the treatment with 3 drugs consisting of a proton pump inhibitor, amoxicillin, and clarithromycin fails, alternative treatment with the following 3 drugs is recommended; AG-Vono Tab 20 mg, 750 mg amoxicillin, and 250 mg metronidazole, orally administered at the same time twice daily for 7 days. The doses of antibiotic should follow the respective label recommendations for H. pylori eradication.

Presentations:

  • AG-Vono Tab 10 mg & Tab 20 mg are available in blister pack of 14’s