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Hertraz

Generic:

Trastuzumab

Therapeutic Class:

Antineoplastic Agent

Composition:

150 mg and 440 mg multi-dose vial containing powder for concentrate for solution for intravenous infusion. Reconstituted Hertraz concentrate contains 21 mg/mL of trastuzumab, a humanised IgG1 monoclonal antibody expressed in Chinese hamster ovary Cells.

Description:

Hertraz (Trastuzumab) is a monoclonal antibody used to treat breast cancer

Indications:

Metastatic Breast Cancer:

Hertraz is indicated for the treatment of adult patients with HER2 positive metastatic cancer (MBC).

Early Breast Cancer:

Hertraz is indicated for the treatment of adult patients with HER2 positive early breast cancer (EBC).

Metastatic Gastric Cancer:

Hertraz in combination with capecitabine or 5-fluorouracil and cisplatin is indicated for the treatment of adult patients with HER2 positive metastatic adenocarcinoma of stomach or gastroesophageal junction who have not received prior anti-cancer treatment for their metastatic disease.

Dosage:

Three – Weekly Schedule:
The recommended initial loading dose is 8 mg/kg body weight. The recommended maintenance dose at threei ntervals is 6 mg/kg body weight, beginning three weeks after the loading units. Weekly Schedule:

The recommended initial loading dose of trastuzumab is 4 mg/kg body weight. The recommended weekly maintenance dose of trastuzumab is 2 mg/kg body weight, beginning one week after the loading dose.