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Hyperbilirubinemic neonates,
especially prematures, should not be treated with Neogene.
Neogene is contraindicated in
neonates if they require treatment with calcium-containing IV solutions,
including continuous calcium-containing infusions such as parenteral
nutrition because of the risk of precipitation of ceftriaxone-calcium.
For the treatment of skin and
skin structure infections, the recommended total daily dose is 50 to 75 mg/kg
given once a day (or in equally divided doses twice a day). The total daily
dose should not exceed 2 grams.
For the treatment of acute
bacterial otitis media, a single intramuscular dose of 50 mg/kg (not to
exceed 1 gram) is recommended.
For the treatment of serious
miscellaneous infections other than meningitis, the recommended total daily
dose is 50 to 75 mg/kg, given in divided doses every 12 hours.
The total daily dose should not
exceed 2 grams.
In the treatment of meningitis,
it is recommended that the initial therapeutic dose be 100 mg/kg (not to
exceed 4 grams). Thereafter, a total daily dose of 100 mg/kg/day (not to
exceed 4 grams daily) is recommended. The daily dose may be administered once
a day (or in equally divided doses every 12 hours). The usual duration of
therapy is 7 to 14 days.
The usual adult daily dose is 1
to 2 grams given once a day (or in equally divided doses twice a day)
depending on the type and severity of infection. The total daily dose should
not exceed 4 grams.
If Chlamydia trachomatis
is a suspected pathogen, appropriate antichlamydial coverage should be added,
because ceftriaxone sodium has no activity against this organism.
For the treatment of
uncomplicated gonococcal infections, a single intramuscular dose of 250 mg is
recommended.
For preoperative use (surgical
prophylaxis), a single dose of 1 gram administered intravenously 1/2 to 2
hours before surgery is recommended.
Generally, Neogene therapy
should be continued for at least 2 days after the signs and symptoms of
infection have disappeared. The usual duration of therapy is 4 to 14 days; in
complicated infections, longer therapy may be required.
When treating infections caused
by Streptococcus pyogenes, therapy should be continued for
at least 10 days. No dosage adjustment is necessary for patients with
impairment of renal or hepatic function.
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