| Poze tablets can be taken once daily with or without meals. Skipping meals, while taking Poze is not advisable since this can lead to hypoglycemia.
Monotherapy:
Poze monotherapy is initiated at 15 mg or 30 mg once daily for those patients whose diabetes is not controlled with diet and exercise.
Dose can be increased up to 45 mg once daily for those patients who do not adequately respond to initial dose of Poze.
Combination therapy:
Combined therapy should be considered for those patients who do not adequately respond to monotherapy with Poze.
Sulfonylureas:
Poze can be initiated with sulfonylureas at 15 mg to 30 mg once daily. If the patient experiences hypoglycemia, dose of sulfonylureas should be adjusted (decreased).
Metformin:
Poze can be initiated with metformin at 15 mg to 30 mg once daily. The therapeutic effects of Poze are seen in combination with metformin in patients regardless of dose (low or high) of metformin which the patients are receiving.
Insulin:
Poze can be initiated with insulin at 15 mg to 30 mg once daily. While giving Poze in combination with insulin, dose of insulin can be decreased by 10% to 25% if the patient is hypoglycemic or if plasma glucose concentrations decrease to less than 100 mg/dl. Further adjustments should be done based on glucose-lowering response. If there is a particular risk of hypoglycemia, patients on insulin should be given 15 mg of Poze once daily initially.
Maximum recommended dose:
The maximum dose of Poze should not exceed 45 mg once daily.
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