Starting dose of Pozemet should be based on the patient’s current treatment
of pioglitazone and/or metformin. Pozemet should be given with meals in
divided daily doses to reduce the gastrointestinal side effects associated
with metformin.
Starting Dose:
For patients inadequately controlled on metformin monotherapy:
Pozemet may be
initiated at either 15 mg/500 mg or 15 mg/850 mg tablet strength based on
usual starting dose of pioglitazone (15-30 mg daily), once or twice daily
and gradually titrated after assessing adequacy of therapeutic response.
For patients who initially responded to pioglitazone monotherapy & require additional glycemic control:
Pozemet may be
initiated at either 15 mg/500 mg twice daily or 15 mg/850 mg tablet
strength once daily based on the usual starting doses of metformin (500 mg
twice daily or 850 mg daily) and gradually titrated after assessing
adequacy of therapeutic response.
For patients switching from combination therapy of pioglitazone plus metformin as separate tablets:
Pozemet may be
initiated with either 15 mg/500 mg or 15 mg/850 mg tablet strengths based
on the dose of pioglitazone and metformin already being taken.
Maximum Recommended Dose:
The maximum recommended dose for pioglitazone is 45 mg & metformin is 2,550 mg daily in adults.
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