Generic:
Brivaracetam
Therapeutic Class:
Antiepileptics
Composition:
- Brivazen 25 mg Film-Coated Tablet:
Each film-coated tablet contains Brivaracetam 25 mg.
- Brivazen 50 mg Film-Coated Tablet:
Each film-coated tablet contains Brivaracetam 50 mg.
- Brivazen 100 mg Film-Coated Tablet:
Each film-coated tablet contains Brivaracetam 100 mg.
- Brivazen 10 mg/ml Oral Solution:
Each ml of oral solution contains Brivaracetam 10 mg.
Description:
Brivazen (Brivaracetam) is an anticonvulsant or anti-seizure medication used to treat partial-onset (focal) seizures in epilepsy.
Indications:
Brivazen is indicated as adjunctive therapy in the treatment of partial-onset seizures, with or without secondary generalization, in adults, adolescents and children from 1 month of age with epilepsy.
Dosage:
The recommended dosage for adults, adolescents and children from 1 month of age is presented below.
| Age and Body Weight |
Initial Dosage |
Minimum and Maximum Maintenance Dosage |
| Adults (16 years and older) |
50 mg twice daily (100 mg per day) |
25 mg to 100 mg twice daily
(50 mg to 200 mg per day) |
| Pediatric patients weighing 50 kg or more |
25 mg to 50 mg twice daily
(50 mg to 100 mg per day) |
25 mg to 100 mg twice daily
(50 mg to 200 mg per day) |
| Pediatric patients weighing 20 kg to less than 50 kg |
0.5 mg/kg to 1 mg/kg twice daily
(1 mg/kg to 2 mg/kg per day) |
0.5 mg/kg to 2 mg/kg twice daily
(1 mg/kg to 4 mg/kg per day) |
| Pediatric patients weighing 11 kg to less than 20 kg |
0.5 mg/kg to 1.25 mg/kg twice daily
(1 mg/kg to 2.5 mg/kg per day) |
0.5 mg/kg to 2.5 mg/kg twice daily
(1 mg/kg to 5 mg/kg per day) |
| Pediatric patients weighing Less than 11 kg |
0.75 mg/kg to 1.5 mg/kg twice daily
(1.5 mg/kg to 3 mg/kg per day) |
0.75 mg/kg to 3 mg/kg twice daily
(1.5 mg/kg to 6 mg/kg per day) |
Use in Adults:
The recommended starting dose is either 50 mg/day or 100 mg/day, based on the physician’s assessment of the required seizure reduction in relation to potential adverse reactions. Based on individual patient response and tolerability, the dose may be adjusted within the effective dose range of 50 mg/day to 200 mg/day.
Adolescents and children weighing ≥50 kg
The recommended starting dose is 50mg/day. Brivaracetam may alternatively be initiated at 100mg/day based on the physician’s assessment of the need for seizure control. The recommended maintenance dose is 100 mg/day. Based on individual patient response, the dose may be adjusted within the effective dose range of 50 mg/day to 200 mg/day.
Use in Children:
Adolescents and children weighing ≥20 kg to <50 kg
The recommended starting dose is 1mg/kg/day. Brivaracetam may alternatively be initiated at doses up to 2mg/kg/day based on the physician’s assessment of the need for seizure control. The recommended maintenance dose is 2mg/kg/day. Based on individual patient response, the dose may be adjusted within the effective dose range of 1mg/kg/day to 4mg/kg/day.
Children weighing ≥10 kg to <20 kg
The recommended starting dose is 1 mg/kg/day. Brivaracetam may alternatively be initiated at doses up to 2.5mg/kg/day based on the physician’s assessment of the need for seizure control. The recommended maintenance dose is 2.5 mg/kg/day. Based on individual patient response, the dose may be adjusted within the effective dose range of 1mg/kg/day to 5 mg/kg/day.
Children weighing <11 kg
The recommended starting dose is 1.5 mg/kg/day. Brivaracetam may alternatively be initiated at doses up to 3mg/kg/day based on the physician’s assessment of the need for seizure control.
Presentations:
- Brivazen 25 mg, 50 mg and 100 mg film-coated tablets are available in packs of 14 tablets each.
- Brivazen Oral Solution 10 mg/ml is available in a 60 ml bottle.
