The maximum recommended dose is 12.5 mg empagliflozin and 1000 mg metformin HCl twice daily. Take twice daily with meals, with gradual dose escalation to reduce the gastrointestinal side effects due to metformin.
- Adults with normal renal function (GFR ≥90 ml/min)
The recommended dose is one tablet twice daily. The dosage should be individualized on the basis of the patient’s current regimen, effectiveness, and tolerability using the recommended daily dose of 10 mg or 25 mg of empagliflozin, while not exceeding the maximum recommended daily dose of metformin.
- For patients switching from separate tablets of empagliflozin and metformin
Patients switching from separate tablets of empagliflozin and metformin should receive the same daily dose of empagliflozin and metformin already being taken or the nearest therapeutically appropriate dose of metformin.
Not recommended in patients with an eGFR less than 45 mL/min/1.73 m2, due to the metformin component |