Calfina Plus contains Tramadol hydrochloride & Acetaminophen. Tramadol is a centrally acting synthetic opioid analgesic. The analgesic profile of tramadol is attributed to the binding of parent and M1 metabolite to μ-opioid receptors and weak inhibition of reuptake of norepinephrine and serotonin.
Acetaminophen is a non-opiate, non-salicylate analgesic. Acetaminophen also has centrally acting analgesic effects