AGP Limited Secures 1st Position at BCSR Awards 2023

AGP collaborates with Childlife Foundation on Children’s Day 2023

AGP Launched Peridots – A Thanda Solution to Acidity, Gas and Indigestion

AGP secures 2nd Position at BCR Awards 2022

AGP wins Top Exporter Award at 6th PPMA Summit

AGP sponsors KDSP Carnival 2023

AGP bags big win at GDEIB Awards 2023

AGP continues partnership with IBA

AGP continues collaboration with TCF

AGP joins hands with SKMF

AGP continues partnership with ACF

AGP conducts Allergy Awareness Session At Pak Turk Maarif

Gong-Ringing Ceremony of AGP at PSX

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MyHep

Generic:

Sofosbuvir

 

Therapeutic Class:

 
Hepatitis C Antivirals  
 

Composition:

 

Each MyHep film coated tablet
contains Sofosbuvir 400 mg

 
 

Description:

 

MyHep (Sofosbuvir) is a
nucleotide analog inhibitor of HCV NS5B polymerase. MyHep is a
direct-acting antiviral agent against the hepatitis C virus

 
 

Indications:

 

MyHep tablet is indicated in combination with other medicinal products for the treatment of chronic hepatitis C (CHC) in adults & for hepatitis C virus (HCV) genotype specific activity.

 
 

Dosage:

 

MyHep tablets treatment should be initiated and
monitored by a physician experienced in the management of patients with
CHC.

The recommended dose is one MyHep 400 mg tablet, taken orally, once daily with food. MyHep tablets should be used in combination with other medicinal products. Monotherapy of MyHep tablets is not recommended.

The recommended co-administered medicinal product(s) and treatment duration for MyHep tablets combination therapy.

Recommended
co-administered medicinal product(s) and treatment duration for MyHep
tablets combination therapy

For Patients* with genotype 1,
4, 5 or 6 CHC:

MyHep + Ribavirin + Peginterferon alfa for 12 weeks a,b
MyHep + Ribavirin (Only for use in patients ineligible or intolerant to peginterferon alfa for 24 weeks

For Patients* with genotype 2 CHC:
MyHep + Ribavirin + Peginterferon alfa for 12 weeksb

For Patients* with genotype 3 CHC:
MyHep + Ribavirin + Peginterferon alfa for 12 weeks b
MyHep + Ribavirin for 24 weeks

For Patients* with CHC awaiting liver transplantation:
MyHep + Ribavirin until liver transplantationc

* Includes patients co-infected with human immunodeficiency virus (HIV).

a. For previously treated patients with HCV genotype 1 infection, no data exists with the combination of MyHep tablets, ribavirin and peginterferon alfa.

b. Consideration should be given to potentially extending the duration of therapy beyond 12 weeks and up to 24 weeks; especially for those subgroups who have one or more factors historically associated with lower response rates to interferon-based therapies (e.g. advanced fibrosis/cirrhosis, high baseline viral concentrations, black race, IL28B non CC genotype, prior null response to peginterferon alfa and ribavirin therapy).

c. See Special patient populations – Patients awaiting liver transplantation below.

The dose of ribavirin, when used in combination with MyHep tablets is
weight-based (<75 kg = 1,000 mg and =75 kg = 1,200 mg) and administered
orally in two divided doses with food.

Dose modification:

Dose reduction of Sofosbuvir 400
mg film-coated tablets is not recommended.


If MyHep is used in combination with peginterferon alfa, and a patient has
a serious adverse reaction potentially related to this drug, the
peginterferon alfa dose should be reduced or discontinued. 


If a patient has a serious adverse reaction potentially related to
ribavirin, the ribavirin dose should be modified or discontinued, if
appropriate, until the adverse reaction abates or decreases in severity.

Ribavirin dose
modification guideline for co-administration with Sofosbuvir 400 mg
film-coated tablets

Reduce ribavirin dose to 600 mg/ day in subjects with no cardiac disease & having haemoglobin <10 g/dL & if haemoglobin is < 8.5 g/dL
discontinue ribavirin.

Reduce ribavirin dose to 600 mg/ day in subjects with history of stable cardiac disease & having > 2 g/dL decrease in haemoglobin during any 4 weeks treatment period.

Once ribavirin has been withheld due to either a laboratory abnormality or
clinical manifestation, an attempt may be made to restart ribavirin at 600
mg daily and further increase the dose to 800 mg daily. However, it is not
recommended that ribavirin be increased to the original assigned dose (1000
mg to 1200 mg daily).

 
 

Presentations:

 

400 mg Tabs 28’s

 

 

Melfax

Generic:

Meloxicam

Therapeutic Class:

Antirheumatic Non-Steroid

Composition:

Each Melfax tablet tablet contains 7.5 mg or 15 mf of meloxicam.

Description:

Melfax is a nonsteroidal
anti-inflammatory drug (NSAID), which selectively inhibits cyclooxygenase-2
(Cox-2). It is an oxicam derivative and has anti-inflammatory, analgesic
and antipyretic activities

Indications:

  • Osteoarthritis
  • Rheumatoid arthritis
  • Low back pain
  • Dysmenorrhoea

Dosage:

  • Tab 7.5 mg , Once daily
  • Tab 15 mg , Once daily

Presentations:

  • 7.5 mg tabs 10’s,
  • 15 mg tabs 10’s,

Mecovate

Generic:

Mecobalamin

 

Therapeutic Class:

 
Vitamin B12 Plain  
 

Composition:

 
  • Each Mecovate tablet contains 500 µg of mecobalamin.
  • Each Mecovate ampoule (1 ml) contains 500 µg of mecobalamin.
 
 

Description:

 

Mecovate contains mecobalamin, a vitamin B12 – coenzyme that occurs in the blood and the cerebrospinal fluid. It is taken up by

nerve tissues more actively and extensively than other homologues of vitamin B12.

 
 

Indications:

 
  • Peripheral neuropathies
  • Injection: Megaloblastic anemia due to vitamin B12 deficiency
 
 

Dosage:

 


Mecovate Tablet:

Adults:The usual daily dose is 3 tablets, equivalent to a total of 1500 µg of mecobalamin, administered orally in 3 divided doses.

Mecovate Injection:
Peripheral Neuropathies: The usual adult dosage is 1 amp, equivalent to 500 µg of mecobalamin administered IM

or IV 3 times a week. The dosage should be adjusted according to age of patient and severity of symptoms.

Megaloblastic Anemia:The usual adult dosage is 1 amp, equivalent to 500 µg of mecobalamin administered IM

or IV 3 times a week. After approximately 2 months of medication, the dose should be reduced to a single

administration of 1 amp at 1- to 3-month intervals for maintenance therapy.

 
 

Presentations:

 
  • Mecovate Tab 500 µg is available in pack of 100’s.
  • Mecovate amp 500 µg is available in pack of 10’s.
 
 
 

Maxna

Generic:

Tranexamic acid

 

Therapeutic Class:

Antifibrinolytic

 

Composition:

Each capsule of Maxna contains 500 mg tranexamic acid.
Each 5 ml ampoule of Maxna contains 500 mg
or 1gm of of tranexamic acid.

 

Description:

Maxna contains tranexamic acid,
an antifibrinolytic agent, used to treat or prevent haemorrhage in a
variety of bleeding disorders.

 

Indications:

  • Dysfunctional uterine bleeding (DUB)
  • Menorrhagia
  • Ante- & post-partum hemorrhages
 

Dosage:

Capsules:
The usual adult dose of capsule is 500 mg three or four times daily depending on the severity of the condition.

 

Injection:
For patients unable to take oral medication, Maxna injection can be administered in a dose of 10 mg/kg bodyweight 3 to 4 times daily.

 

Presentations:

  • 500 mg caps 20’s,
  • 500 mg Inj 10’s,
  • 1 gm Inj 10’s,
 

Magnus MR

Generic:

Morphine Sulphate

 

Therapeutic Class:

 

Narcotic analgesic

 
 

Composition:

 

Magnus MR 10 mg capsule,
containing morphine sulphate 10 mg Magnus MR 30 mg capsule, containing
morphine sulphate 30 mg

 
 

Description:

 

Morphine applies an agonist
effect at saturable opioid receptors in the CNS and other tissues &
acts as opioid analgesic.

 
 

Indications:

 

Severe chronic pain or pain
resistant to other analgesics, in particular pain associated with cancer.

 
 

Dosage:

 

Adults:


Recommended dosage is one capsule twice daily, at 12-hour intervals.

Elderly:


As with all narcotics a reduction in dosage may be advisable in the
elderly, as appropriate.

 
 

Presentations:

 

10 mg tab 30’s
30 mg tab 30’s

 

 

 

Lucast

Generic:

Montelukast
sodium

 

Therapeutic
Class:

 
Antileuk Anti-Asthm Sys  
 

Composition:

 

Lucast 4 mg Sachet:
Each sachet contains Montelukast 4 mg (as sodium salt).

Lucast 4 mg Tablets:
Each chewable tablet contains Montelukast 4 mg (as sodium salt).

Lucast 5 mg Tablets:
Each chewable tablet contains Montelukast 5 mg (as sodium salt).

Lucast 10 mg Tablets:
Each tablet contains Montelukast 10 mg (as sodium salt).

 
 

Description:

 

Lucast
contains montelukast sodium, a relatively new and effective therapy
recommended by international and national guidelines for the control
(prevention) of acute and chronic asthmatic attacks.

 
 

Indications:

 
Asthma:

Lucast
is indicated for the prophylaxis and chronic treatment of
asthma in adults and pediatric patients 12 months of age and older.

Allergic Rhinitis:

Lucast
is indicated for the relief of symptoms of:

  • Seasonal allergic rhinitis in patients 2 years of age and older
  • Perennial allergic rhinitis in patients 6 months of age and older.

Exercise-Induced Bronchoconstriction (EIB):

Lucast
is indicated for prevention of exercise-induced bronchoconstriction (EIB)
in patients 6 years of age and older.

 
 

Dosage:

 
Asthma:

Lucast
should be taken once daily in the evening. The following doses are
recommended:

For
adults and adolescents 15 years of age and older:
 One Lucast 10 mg tablet.

For
pediatric patients 6 to 14 years of age:
 One
Lucast 5 mg chewable tablet.

For
pediatric patients 2 to 5 years of age:
 One
Lucast 4 mg chewable tablet or one Lucast 4 mg sachet.

For
pediatric patients 12 to 23 months of age:
 One Lucast 4 mg sachet.

Safety
and effectiveness in pediatric patients less than 12 months of age with
asthma have not been established.

Allergic Rhinitis:

For
allergic rhinitis, Lucast should be taken once daily.

Seasonal
allergic rhinitis

The
following doses for the treatment of symptoms of seasonal allergic rhinitis
are recommended:

For
adults and adolescents 15 years of age and older
: One Lucast 10 mg tablet.

For
pediatric patients 6 to 14 years of age
: One Lucast 5 mg chewable tablet.

For
pediatric patients 2 to 5 years of age
: One Lucast 4 mg chewable tablet or One Lucast 4 mg
sachet.

Safety
and effectiveness in pediatric patients younger than 2 years of age with
seasonal allergic rhinitis have not been established.

Perennial
allergic rhinitis

The
following doses for the treatment of symptoms of perennial allergic
rhinitis are recommended:

For
adults and adolescents 15 years of age and older
: One Lucast 10 mg tablet.

For
pediatric patients 6 to 14 years of age
: One Lucast 5 mg chewable tablet.

For
pediatric patients 2 to 5 years of age
: One Lucast 4 mg chewable tablet or One Lucast 4 mg
sachet.

For
pediatric patients 6 to 23 months of age
: One Lucast 4 mg sachet.

Safety
and effectiveness in pediatric patients younger than 6 months of age with
perennial allergic rhinitis have not been established.

Asthma and Allergic Rhinitis:

Patients
with both asthma and allergic rhinitis should take only one Lucast dose
daily in the evening.

Exercise-Induced Bronchoconstriction (EIB):

For
prevention of EIB, a single dose of Lucast should be taken at least 2 hours
before exercise. The following doses are recommended:

For
adults and adolescents 15 years of age and older
: One Lucast 10 mg tablet.

For
pediatric patients 6 to 14 years of age
: One Lucast 5 mg chewable tablet.

An
additional dose of Lucast should not be taken within 24 hours of a previous
dose. 

 
 

Presentations:

 
  • 4   mg   Sachet 14’s
  • 10 mg   Tabs 10’s
  • 5   mg   Tabs 10’s
  • 4   mg   Tabs 14’s
 
 
 
 

Kefzol

Generic:

Cefazolin

 

Therapeutic Class:

Cephalosporins Inject

 

Composition:

Kefzol (sterile cefazolin
sodium) is a semisynthetic cephalosporin antibiotic

 

Description:

Kefzol is first generation cephalosporin antibiotic for parenteral administration covering Gram positive cocci & Gram negative bacteria

 

Indications:

  • Cesarean section
  • Biliary surgery
  • Gastrointestinal surgery
  • Vaginal hysterectomy
  • Abdominal hysterectomy
 

Dosage:

Children:
Mild to moderate infections: 25-50 mg/kg/day divided in 3-4 equal doses.
Severe Infections: 100 mg/kg/day divided in 3-4 equal doses.

Adults:
Mild to moderate infections: 500 mg t.i.d. or 1 g b.i.d

 

Presentations:

500 mg Inj 1’s
1 gm Inj 1’s

 

Keflex

 

Generic:

Cephalexin

 

Therapeutic
Class:

 

Cephalosporins Oral

 
 

Composition:

 

Capsules:


Keflex capsules containing cephalexin monohydrate equivalent to 250 mg or 500 mg are available for oral administration.

Powder for Oral Suspension:
Keflex bottles containing cephalexin powder for oral suspension equivalent to 125 mg/5 ml and 25O mg/5 ml after mixing are available for oral administration.

Powder for Oral Drops:
Keflex bottles containing cephalexin powder for oral suspension equivalent to 100 mg/ml after mixing are available for oral administration

 
 

Description:

 

Keflex is first generation cephalosporin antibiotic for oral administration, covering Gram positive bacteria

 
 

Indications:

 
  • Respiratory tract infections
  • Urinary tract Infections
  • Otitis media
  • Skin & soft tissue infections
  • Bone infection
  • Dental infections
 
 

Dosage:

 

Children: 

25-50 mg/kg body weight in divided doses. In severe infections, the dosage may be doubled. In the therapy of otitis media, clinical studies have shown that a dosage of 75-100 mg/kg body weight in 4 divided doses is required.

Adults:

Dosage ranges from 1-4 g daily in divided doses. The usual adult dose is 250 mg every 6 hours

 
 

Presentations:

 
  • 250 mg caps 12’s
  • 500 mg caps 12’s
  • 125 mg susp 60 ml
  • 250 mg susp 60 ml
  • 100 mg drops 10 ml
 
 
 

 

 

Gluconormet

Generic:

Glimepiride, Metformin HCl

Therapeutic Class:

Biguanide & S-Urea Combs

Composition:

Each Gluconormet (1 mg/ 500 mg)
contains glimepiride 1 mg and metformin hydrochloride 500 mg.

Each Gluconormet (2 mg/ 500 mg)
contains glimepiride 2 mg and metformin hydrochloride 500 mg.

Description:

Gluconormet is an oral antidiabetic agent (glimepiride & metformin HCl) used in the management of type 2 diabetes.

Glimepiride:
Glimepiride (sulphonylurea class), mechanism of action appears to be
dependent on stimulating the release of insulin from functioning pancreatic
beta cells.


Metformin HCl:
Metformin improves glucose tolerance in patients with type 2 diabetes,
lowering both basal and postprandial plasma glucose.

Indications:

Gluconormet is indicated in the
treatment of patients with type 2 diabetes mellitus when diet, exercise and
single agent do not result in adequate glycemic control.

Dosage:

Gluconormet should be given once daily with full meal preferably in the evening. Therapy should be started with Gluconormet (glimepiride 1 mg & metformin 500 mg) one tablet daily. Depending upon the glycemic control, dose may be titrated to 2 tablets once daily.

Alternatively, the therapy may be started with Gluconormet (glimepiride 2 mg & metformin hydrochloride 500 mg) one tablet daily. Depending upon the glycemic control, dose may be titrated to 2 tablets once daily. The maximum daily dose of glimepiride is 8 mg and of metformin is 2000 mg.

Presentations:

  • Gluconormet (1 mg/500 mg) tablet is available in pack of 30’s.
  • Gluconormet (2 mg/500 mg) tablet is available in pack of 30’s.
 

Gluconorm

 

Generic:

Glimepiride

 

Therapeutic
Class:

Sulphonylurea A-Diabs
 

Composition:

Each
Gluconorm tablet contains glimepiride 1 mg, 2 mg, 3 mg or 4 mg as active
ingredient.
 

Description:

Gluconorm
(glimepiride) is an oral blood-glucose-lowering drug of the sulfonylurea
class.
 

Indications:

Gluconorm
is indicated:

– As
an adjunct to diet and exercise to lower the blood glucose in patients with
noninsulin-dependent (Type 2) diabetes mellitus (NIDDM) whose hyperglycemia
cannot be controlled by diet and exercise alone. 

– Concomitantly with metformin when diet, exercise and Gluconorm or metformin alone do not result in adequate glycemic control.

– In combination with insulin to lower blood glucose in patients whose hyperglycemia cannot be controlled by diet and exercise in conjunction with an oral hypoglycemic agent. Combined use of glimepiride and insulin may increase the potential for hypoglycemia.

 

Dosage:

Usual
Starting Dose
:

The usual starting dose of Gluconorm as initial therapy is 1-2 mg once daily, administered with breakfast or the first main meal.

The maximum starting dose of Gluconorm should be no more than 2 mg. 

Usual Maintenance Dose:
The usual maintenance dose is 1 to 4 mg once daily.

The maximum recommended dose is 8 mg once daily. 

Gluconorm-Metformin Combination Therapy:
If patients do not respond adequately to the maximal dose of Gluconorm monotherapy, addition of metformin may be considered.

With concomitant Gluconorm and metformin therapy, the desired control of blood glucose may be obtained by adjusting the dose of each drug. 

Gluconorm-Insulin Combination Therapy:
Combination therapy with Gluconorm and insulin may also be used in secondary failure patients. The recommended Gluconorm dose is 8 mg once daily administered with the first main meal.

After starting with low-dose insulin, upward adjustments of insulin can be done approximately weekly as guided by frequent measurements of fasting blood glucose.

 

Presentations:

  • Gluconorm 1 mg tablet is available in pack of 20’s.
  • Gluconorm 2 mg tablet is available in pack of 20’s.
  • Gluconorm 3 mg tablet is available in pack of 20’s.
  • Gluconorm 4 mg tablet is available in pack of 20’s.